Patented technology of 4SC which simulates the principle of high throughput screening on the computer in order to generate new molecules for biology and chemistry research.
Improvement in the disease by at least 20% compared to the base value, i.e. reduction of 20% in the number of swollen and tender joints, and a reduction of 20% in three of the following five parameters: physician’s overall assessment of disease activity, patient’s overall assessment of disease activity, patient’s assessment of pain, C-reactive protein or erythrocyte sedimentation rate in blood, and degree of physical disability in Health Assessment Questionnaire (HAQ) score.
Improvement in the disease by 50% over the base value. For the parameters, see ACR20.
Improvement in the disease by 70% over the base value. For the parameters, see ACR20.
ACUTE MYELOID LEUKAEMIA
Malignant form of cancer affecting part of the haemopoietic system.
Abbreviation for adverse events.
Abbreviation for available for sale, one of four categories of financial instruments.
Abbreviation for at fair value through profit or loss, one of four categories of financial instruments.
Abbreviation for acute myeloid leukaemia.
Inhibiting mitosis, i.e. cell nucleus division.
The process of programmed cell death. This process can be caused by external factors, for example it may be triggered by immune cells, or may be activated due to cellular processes such as a damaged genome. Apoptosis is actively conducted by the cell´s internal components and results in destruction of the cell.
Illness that cause the body’s immune system to attack its own tissue.
German abbreviation for the German Federal Ministry of Education and Research.
Compound Annual Growth Rate. The annualised growth rate of an investment over a specifi ed period of time.
Abbreviation for colitis activity index; this index is used for determining disease activity in patients suffering from ulcerative colitis.
Abbreviation for Crohn's disease activity index; this index is used for determining disease activity in patients suffering from Crohn's disease.
Conrad Hinrich Donner Bank.
Trials (Phase I through III) in drug development that are conducted in healthy subjects and patients.
Abbreviation for colorectal cancer.
Autoimmune disease resulting in chronic inflammation of the intestine.
Directors & Officers insurance.
“Disease activity score”; system that serves to measurethe activity of the disease in RA patients based on 28 defined joints.
Dihydroorotate dehydrogenase; enzyme which plays an important role in building DNA in the cell.
Concept of corporate governance, that takes into account the diversity of people and functions among a company's workforce, management and Supervisory Board.
Disease-modifying anti-rheumatic drugs; agents that alter the course and progression of rheumatoid arthritis.
Deoxyribonucleic acid is a biological molecule that contains the genetic information in a cell and codes the blueprint for making the proteins.
Abbreviation for duration of response.
Kinesin spindle protein which plays a role in the distribution of chromosomes to the daughter cells during cell division.
Abbreviation for epidermal growth factor receptor; a transmembrane receptor with intrinsic tyrosine kinase activity that is highly regulated and/ or found in mutated form in many types of tumours, thus leading to uncontrolled cell growth.
General result of a study that evaluates the outcome of the individual steps based on a clinical trial protocol.
Protein which enables or accelerates chemical reactions in cells by acting as a catalyst.
Method used in annual financial statements to account for an entity’s investment in another entity’s voting capital.
Abbreviation for employee stock option programme.
Abbreviation for “first in, first out”; a procedure related to the measurement of inventories and their utilisation in connection with fluctuating procurement prices.
Voluntary, usually healthy person participating in a clinical study.
Chemotherapy scheme for treating colon cancer.
Abbreviation for hepatocellular carcinoma.
Abbreviation for histone deacetylase.
Histone deacetylase inhibitor designed to prevent the cell division process of tumours directly and in a targeted way.
Malignant tumour triggered by the hepatocytes of the liver’s tissue; the most common form of liver cancer.
Abbreviation for Hodgkin’s lymphoma.
Hodgkin’s lymphoma is a malignant tumour in the lymph nodes.
Abbreviation for held to maturity, one of four categories of financial instruments.
Abbreviation for International Accounting Standards.
Abbreviation for International Accounting Standards Board.
Abbreviation for inflammatory bowel disease.
Abbreviation for International Financial Reporting Interpretations Committee.
Abbreviation for International Financial Reporting Standards.
Abbreviation for interleukin-17, a cytokine regulating cell growth and differentiation.
Annual test of recognised goodwill for impairment.
INFLAMMATORY BOWEL DISEASE (IBD)
A group of inflammatory conditions that recurr in the gastrointestinal tract, including the small intestine and colon; Crohn’s disease and ulcerative colitis are the main types.
Substance that inhibits a specific enzyme reaction.
Abbreviation for international nonproprietary name, which is granted by the WHO.
Description based on silicon, the chemical element used to manufacture computer chips. Computer-based simulation of biochemical processes and examination of the effi cacy of molecules.
Experiments that take place in a controlled, artificial environment outside of the living organism, e.g. in a test tube.
Experiments that take place in the living organism, e.g. in animal testing.
Protein which controls cellular signal transfer.
Abbreviation for loans and receivables, one of four categories of financial instruments.
Autoimmune disease, frequently accompanied by joint pain similar to rheumatism; inflammation may also occur in the heart, lungs, kidneys and brain.
MEDICAL ETHICS COMMITTEE
Assessment of ethical and legal aspects of medical research in human beings; the medical ethics committee must approve the commencement of clinical studies.
Abbreviation for multiple sclerosis.
Autoimmune disease of the central nervous system which results in degeneration of the nerve sheath.
Collective term for nervous system diseases.
Abbreviation for objective overall response rate.
Abbreviation for overall survival.
Granting of a license to a third party to use one or more industrial property rights.
Abbreviation for progression free survival.
Abbreviation for progression free survival rate.
Study of the efficacy of drugs in a living organism.
Spatial and temporal distribution of compounds throughout the various tissues of anorganism.
Clinical trial of a drug conducted in a small number of healthy patients subject to strict controls; serves to test the tolerance, pharmacokinetics, method of administration and safe dose of the compound.
Clinical trial conducted in a small number of patients subject to strict controls to identify a compound’s sudden side effects and risks; determination of the efficacy of the drug and any potential side effects.
Study conducted in a large number of patients (between several hundred and several thousand) to determine the safety, efficacy and optimum dosage of a drug under real therapeutic conditions.
Laboratory tests related to a new drug candidate conducted in animals, organs or cell cultures in order to obtain satisfactory evidence that a clinical study is justified and that the drug candidate is classified as safe.
Listing segment of Deutsche Börse with clearly defined transparency requirements.
Milestone proving a drug candidate’s efficacy in medical terms, usually in Phase II.
Multi-protein complex for the decomposition of used cellular products.
Large complex molecule composed of amino acids. Proteins are essential to the structure, regulation and function of all organisms; typical proteins include enzymes and antibodies.
Abbreviation for rheumatoid arthritis.
Abbreviation for response evaluation criteria in solid tumours; guidelines on the evaluation of therapeutic success in solid tumours.
Autoimmune disease of the connective tissue, especially the joints.
Compensation for the use of third-party rights to intellectual property. Royalties are generally calculated as a certain percentage of the revenue generated from the intellectual property rights.
Abbreviation for serious adverse events.
Abbreviation for Standing Interpretations Committee.
Class of hormones such as cholesterol which has an anti-inflammatory effect.
Specific biological molecule, e.g. an enzyme or receptor, which plays an important role in the origination or development of a disease. Compounds/drugs develop their therapeutic activity by binding to a target molecule.
Specific influencing and controlling of signalling pathways in cancer and autoimmune diseases.
Drug derived from natural cytotoxins. It inhibits cell growth by attacking the spindle apparatus during cell
Undesirable side effects of a substance depending on its dose.
Field of science examining the effects of toxic substances or the toxicity of substances.
Abbreviation for time to progression.
Cellular components which play a significant role in cell division, among others.
Chronic inflammatory disease of the mucous membranes of the large intestine.
World Health Organization; the United Nations agency responsible for international public health.